Pre-Implantation Genetic Screening (PGS)
Pre-Implantation Genetic Screening (PGS), also known as Embryo Screening, is performed to check for any chromosomal abnormalities in all 24 chromosomes caused by missing or additional chromosomes. Chromosomal abnormalities include Trisomy 13 (Patau's syndrome), Trisomy 18 (Edward’s syndrome) and Trisomy 21 (Down syndrome). CCS also includes the screening of chromosomes X and Y, making Family Balancing through Gender Selection possible.
With over 60 years of collective experience and five locations across Michigan and Ohio, the physicians of IVF Michigan Fertility Center are available to help couples throughout the Midwest and abroad.
What are the advantages of completing IVF with PGS?
- Detect any missing or additional chromosomes
- Prevent trisomies such as Down syndrome, Edward's syndrome and Patau's syndrome
- Identify the gender of embryos
- Embryos without chromosomal abnormalities are at lower risk for miscarriage
Who is recommended to complete IVF with PGS?
PGS is typically recommended for couples with:
- Advanced maternal age
- Low quality sperm
- A history of recurrent miscarriage or IVF failures
- Concern for Down syndrome
- Interest in Gender Selection
What are the steps in an IVF journey with PGS?
Completing PGS with an IVF-ICSI cycle does not change the duration of treatment. Following Egg Retrieval, if the eggs are fertilized successfully, a biopsy is taken from each embryo and tested through PGS. The healthy embryos of the desired gender are then transferred to the uterus. The following steps take place over 15 to 20 days.
Ovarian Stimulation (7 to 10 days):
On Day 2 or 3 of the Menstrual cycle, medication is prescribed to stimulate the growth of multiple follicles in the ovaries. During this time, follicular growth is monitored through ultrasound as they develop into eggs and hormone levels are tracked through blood tests. Medication protocols are changed as needed. 36 – 40 hours before the scheduled Egg Retrieval, an hCG “trigger” shot is given to induce maturation of the eggs within a scheduled timeframe.
Egg Retrieval (OPU):
Eggs are retrieved using a thin ultrasound-guided needle during a short procedure under sedation. The number of eggs retrieved depends on the body's response to the medication.
Sperm Collection and ICSI:
On the day of Egg Retrieval, a semen sample is taken to fertilize the retrieved eggs. To increase chances of fertilization, a single sperm is injected into each egg using a precision needle in a method called ICSI.
Pre-Implantation Genetic Screening (PGS):
Pre-Implantation Genetic Screening (PGS) will be completed for family balancing or to screen for any chromosomal abnormalities. 3 to 5 days after the Egg Retrieval, a biopsy is taken from each embryo and tested in the Genetics Lab. The health and gender of the embryos is identified and discussed with you before Embryo Transfer.
Embryo Transfer (ET):
Embryo Transfer is a minor procedure that does not require sedation. Following the procedure, hormone levels are tracked through blood test to confirm pregnancy. Any embryos that are not transferred may be frozen and used in a future cycle.