Genetic Testing at IVF Michigan Fertility Center

IVF Michigan Fertility Center's medical team includes experts in all aspects of Reproductive Medicine, including IVF and Urology. Their education and extensive experience in the field allows IVF Michigan Fertility Center to continually improve medical protocols, contributing to one of the highest success rates in the nation. IVF Michigan Fertility Center's medical team prides themselves on playing a role in the advancement of medicine as recognized leaders in the treatment of infertility.


As part of IVF Michigan Fertility Center's mission to fulfill dreams of parenthood through the delivery of healthy babies, IVF Michigan Fertility Center offers a number of genetic testing services. With over 60 years of collective experience and locations in Bloomfield Hills, Ann Arbor, Dearborn, Saginaw and Toledo, OH, the physicians of IVF Michigan Fertility Center are available to help couples throughout the Midwest and abroad. IVF Michigan Fertility Center's Genetic Testing services include those that are performed during IVF, screening tools to identify carriers of hereditary diseases and genetic testing during pregnancy.
Genetic Testing during IVF IVF Michigan Fertility Center Shamma Hammoud Fakih


Genetic Testing and IVF

Completing Genetic Testing during an IVF-ICSI cycle provides a wealth of information about each embryo before transferring to the uterus. During an IVF cycle, following Egg Retrieval (OPU) and ICSI, when the egg and sperm have fertilized to form an embryo, a few cells are taken from the embryo to be tested in the Genetics Laboratory. The Embryo Transfer takes place after the results of the genetic test are released. Completing Genetic Testing does not alter the duration of treatment.

Pre-Implantation Genetic Screening (PGS): Screen all 24 chromosomes for gender as well as any chromosomal abnormalities caused by missing or additional chromosomes. Chromosomal abnormalities include Trisomy 13 (Patau's syndrome), Trisomy 18 (Edward’s syndrome) and Trisomy 21 (Down syndrome). Chromosomal abnormalities are the leading cause of miscarriage.

Gender Selection: Screen your embryos to identify the gender and check for chromosomal abnormality such as Down Syndrome. 

Pre-Implantation Genetic Diagnosis (PGD) for Hereditary Disease or Single Gene Disorders: Assess embryos for hereditary diseases, allowing parents with a known hereditary (genetic) disease to ensure their children do not have that genetic condition.  

HLA Matching - Curing a Family Member: Cure a family member suffering from a hereditary disease curable by bone marrow transplant by identifying an HLA Match during IVF. 


Identify & Prevent Hereditary Disease 

Based on individual needs, a genetic counselor may recommend that screening be completed in order to  identify if you are a carrier of a hereditary disease. If a genetic mutation is found, Pre-Implantation Genetic Diagnosis (PGD) during an IVF cycle is utilized in order to avoid passing on the hereditary disease or medical protocols may be altered during treatment in order to optimize the outcome.   

Identifying Hereditary Disease: Most carriers of mutations of the disease have no symptoms and are not affected. However, if you and your partner are carriers for the same mutation, your child is at a significantly higher risk of being affected with that disease. IVF Michigan Fertility Center offers the Counsyl Universal Genetic Test, a genetic screening test that screens parents for more than 100 single gene disorders including cystic fibrosis, spinal muscular atrophy (SMA), Tay-Sachs disease and Sickle Cell disease.

Mutation Screening is a tool for couples to identify if they are carriers of a heredity disease. Mutation Screening by Sanger Sequencing is most often recommended when the genetic disease has previously been identified or there is a known family history for a particular genetic disease. Mutation Screening is used to detect genetic diseases caused by a few number of mutations or for detecting mutations in small genes. If a mutation is identified,  Pre-Implantation Genetic Diagnosis (PGD) completed during an IVF cycle is used in order to ensure that the genetic disease will not affect your children.


Genetic Testing during Pregnancy 

IVF Michigan Fertility Center offers two genetic testing services for pregnant women. The first, Non-Invasive Prenatal Diagnosis through the Verifi® prenatal test, is an additional screening tool for pregnant women to ensure the health of their baby through a non-invasive method at an earlier stage than was possible with conventional screening tools. The gender of the fetus may also be identified. The second test is a tool for women who are experiencing miscarriages and are interested in identifying the cause of the aborted pregnancy by completing a chromosomal analysis of their Products of Conception. 

Non-Invasive Prenatal Diagnosis (NIPD): Screen for Trisomy 13, 18 or 21 (Down syndrome) and identify the gender of your fetus through a non-invasive blood test at 10 weeks. IVF Michigan Fertility Center completes NIPD using the Verifi Prenatal Test. 

Products of Conception (POC): Fetal loss is the most common pregnancy complication, occurring in 25-30% of recognized pregnancies. Chromosomal analysis on Products of Conception may help identify the cause of pregnancy loss and improve management of future pregnancies by considering Assisted Reproductive Techniques and Pre-Implantation Genetic Screening to avoid the recurrence of miscarriages.


To learn more about any of the services described above or to discuss your personal case,  book an appointment today.